Properties of naphtho[2,1-b]pyrans covalently linked to oligonucleotides

被引：3

作者：

Mazzei, M ^{[1
]}

Sottofattori, E ^{[1
]}

Ibrahim, M ^{[1
]}

Balbi, A ^{[1
]}

机构：

[1] Dept Pharmaceut Sci, I-16132 Genoa, Italy

来源：

NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 9-11期

关键词：

D O I：

10.1080/07328319808004727

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two naphtho[2,1-b]pyrans (benzocoumarin 1 and benzochromone 2) were covalently linked to a 7-mer ODN. Purification and hydrophobicity studies of the resulting conjugates 1* and 2* were performed by HPLC. Benzochromone conjugate 2* was more hydrophobic than benzocoumarin conjugate 1*. Preliminary data on thermal stability and interaction with HIV reverse transcriptase showed that 1* is slightly more efficient than 2*. This is probably due to the steric hindrance of the 3-diethylamino group in 2.

引用

页码：1885 / 1894

页数：10

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