Properties of naphtho[2,1-b]pyrans covalently linked to oligonucleotides

被引:3
作者
Mazzei, M [1 ]
Sottofattori, E [1 ]
Ibrahim, M [1 ]
Balbi, A [1 ]
机构
[1] Dept Pharmaceut Sci, I-16132 Genoa, Italy
来源
NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 9-11期
关键词
D O I
10.1080/07328319808004727
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two naphtho[2,1-b]pyrans (benzocoumarin 1 and benzochromone 2) were covalently linked to a 7-mer ODN. Purification and hydrophobicity studies of the resulting conjugates 1* and 2* were performed by HPLC. Benzochromone conjugate 2* was more hydrophobic than benzocoumarin conjugate 1*. Preliminary data on thermal stability and interaction with HIV reverse transcriptase showed that 1* is slightly more efficient than 2*. This is probably due to the steric hindrance of the 3-diethylamino group in 2.
引用
收藏
页码:1885 / 1894
页数:10
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