Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology

被引：104

作者：

Han, JH ^{[1
]}

Molkentin, JD

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[2] Childrens Hosp, Med Ctr, Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2000年 / 10卷 / 01期

关键词：

D O I：

10.1016/S1050-1738(00)00039-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myocyte enhancer factor-2 (MEF2), transcription factors and mitogen-activated protein kinase (MAPK) p38 are regulators of cardiac development and various pathophysiologic processes. The recent finding that p38 can directly regulate MEF2 transcription factors suggests a novel mechanism for reprogramming cardiac gene expression in response to neuroendocrine and/or stress stimulation. This review weighs the accumulating evidence for a p38 MAPK-MEF2 signal transduction cascade and discusses ifs role in cardiac myocyte biology. (Trends Cardiovasc Med 2000; 10:19-22). (C) 2000 Elsevier Science Inc.

引用

页码：19 / 22

页数：4