Free-energy landscape of enzyme catalysis

被引：207

作者：

Benkovic, Stephen J. ^{[2
]}

Hammes, Gordon G. ^{[1
]}

Hammes-Schiffer, Sharon ^{[2
]}

机构：

[1] Duke Univ, Dept Biochem, Durham, NC 27710 USA

[2] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

BIOCHEMISTRY | 2008年 / 47卷 / 11期

关键词：

D O I：

10.1021/bi800049z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The concept is developed that enzyme mechanisms should be viewed as "catalytic networks" with multiple conformations that occur serially and in parallel in the mechanism. These coupled ensembles of conformations require a multi-dimensional standard free-energy surface that is very "rugged", containing multiple minima and transition states. Experimental and theoretical evidence is presented to support this concept.

引用

页码：3317 / 3321

页数：5