Bastadin 20 and bastadin O-sulfate esters from Ianthella basta: Novel modulators of the Ry(1)R FKBP12 receptor complex

被引：62

作者：

Franklin, MA

Penn, SG

Lebrilla, CB

Lam, TH

Pessah, IN

Molinski, TF

机构：

[1] UNIV CALIF DAVIS,DEPT CHEM,DAVIS,CA 95616

[2] UNIV CALIF DAVIS,DEPT MOL BIOSCI,DAVIS,CA 95616

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 12期

关键词：

D O I：

10.1021/np960507g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

New compounds bastadin 20 (9), 15,34-O-disulfatobastadin 7 (10), and 10-O-sulfatobastadin 3 (11) were isolated from Ianthella basta collected in Exmouth Gulf, Western Australia. Compounds 10 and 11 exhibited moderate differential activity as SR Ca2+ channel agonists (EC(50) 13.6 and 100 mu M, respectively) of the Ry(1)R FKBP12 complex, while the potency of 9 was almost half that of 10 (EC(50) 20.6 mu M). The problem of dereplication of bastadins was addressed using H-1-NMR ''fingerprinting'' of MeO signals in the corresponding permethyl bastadin derivatives.

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页码：1121 / 1127

页数：7

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