Hydrophobicity parameters determined by reversed-phase liquid chromatography for some new isoxazolyl-naphthoquinones

被引：11

作者：

Granero, GE ^{[1
]}

de Bertorello, MM ^{[1
]}

Briñón, MC ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farm, RA-5000 Cordoba, Argentina

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 1999年 / 22卷 / 02期

关键词：

D O I：

10.1081/JLC-100101656

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipophilic character of a series of new isoxazolylnaphthoquinones has been studied. Partition chromatography procedures (RP-HPLC and RP-TLC) were developed for determining the log Po-w (n-octanol/water partition coefficient) values. The experimental values from these methods were validated by comparison with those obtained from the conventional shake flask method, except with the more lipophilic 4, 6 and 7 because they have poor water solubility. Also, the log Po-w was calculated using a CLOGP computer programme.

引用

页码：229 / 240

页数：12

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