Apoptosis regulators and their role in tumorigenesis

被引：187

作者：

Zörnig, M

Hueber, AO

Baum, W

Evan, G

机构：

[1] Georg Speyer Haus, D-60596 Frankfurt, Germany

[2] CNRS, Inst Signaling Dev Biol & Canc Res, UMR 6543, Ctr Antoine Lacassagne, F-06189 Nice, France

[3] Univ Calif San Francisco, Ctr Canc, San Francisco, CA 94143 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2001年 / 1551卷 / 02期

关键词：

apoptosis; tumorigenesis; programmed cell death;

D O I：

10.1016/S0304-419X(01)00031-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has become clear that, together with deregulated growth, inhibition of programmed cell death (PCD) plays a pivotal role in tumorigenesis. In this review, we present an overview of the genes and mechanisms involved in PCD. We then summarize the evidence that impaired PCD is a prerequisite for tumorigenesis, as indicated by the fact that more and more neoplastic mutations appear to act by interfering with PCD. This has made the idea of restoration of corrupted 'death programs' an intriguing new area for potential cancer therapy. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：F1 / F37

页数：37

共 392 条

[1] TARGETED MUTATION IN THE FAS GENE CAUSES HYPERPLASIA IN PERIPHERAL LYMPHOID ORGANS AND LIVER [J].