Toll-like receptors and their role in host resistance to Toxoplasma gondii

被引：43

作者：

Yarovinsky, Felix ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Immunol, Dallas, TX 75390 USA

来源：

IMMUNOLOGY LETTERS | 2008年 / 119卷 / 1-2期

关键词：

Toxoplasma gondii; Toll-like receptors; TLR11; TLR2; MyD88; IL-12; IFN-gamma; dendritic cells;

D O I：

10.1016/j.imlet.2008.05.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toxoplasma gondii and other apicomplexan parasites are widely distributed obligate intracellular protozoa. A critical host mediator produced in response to T gondii infection is IL-12. This cytokine is synthesized by dendritic cells, macrophages and neutrophils and plays a pivotal role in the production of IFN-gamma, which in turn activates anti-microbial effector cells. in the past several years, many of the receptors and signaling pathways that link pathogen detection to induction of IL-12 have been identified and characterized. Among these receptors the Toll-like receptor (TLR) family can recognize all classes of pathogens and induce different types of immune responses. In the following review, I summarize the evidence for specific TLR function in host resistance to T. gondii. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：17 / 21

页数：5

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