A cryotrap as flow reactor for synthesis of 211At labelled compounds

被引：11

作者：

Koziorowski, J

Lebeda, O

Weinreich, R ^{[1
]}

机构：

[1] Univ Zurich, Inst Med Radiobiol, CH-5232 Villigen, Switzerland

[2] Paul Scherrer Inst, CH-5232 Villigen, Switzerland

[3] Acad Sci Czech Republic, Inst Nucl Phys, CZ-25068 Rez, Czech Republic

来源：

APPLIED RADIATION AND ISOTOPES | 1999年 / 50卷 / 03期

关键词：

radiotherapeutics; (211)At; labelling technique; cryotrapping;

D O I：

10.1016/S0969-8043(98)00070-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new simplified approach for the preparation of (211)At-labelled compounds is presented. The labelling procedure is carried out entirely in a Teflon capillary which also serves as a cryotrap. Two organic astatine compounds were synthesized by this method: 5-[(211)At]astato-2'-deoxyuridine (AUdR) and N-succinimidyl-4-[(211)At]astatobenzoate (SAB), starting from their respective stannylated precursors. The first reaction was performed in aqueous solution and the latter in an organic solvent using Iodogen as the oxidant in both cases. Overall radiochemical yields were approximately 75% for AUdR and approximately 70% for SAB. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：527 / 529

页数：3

共 9 条

[1] Radiosynthesis and quality assurance of 5-[124I]Iodo-2′-deoxyuridine for functional PET imaging of cell proliferation [J].