Simple preparation of Br-76, I-123 and At-211 labeled 5-halo-2'-deoxyuridine

被引：6

作者：

Koziorowski, J

Weinreich, R

机构：

[1] PAUL SCHERRER INST,INST MED RADIOBIOL,CH-5232 VILLIGEN PSI,SWITZERLAND

[2] UNIV UPPSALA,INST CHEM,DEPT ORGAN CHEM,S-75121 UPPSALA,SWEDEN

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 1997年 / 219卷 / 01期

关键词：

Oxidation; Physical Chemistry; Inorganic Chemistry; Halogen; Deoxyuridine;

D O I：

10.1007/BF02040279

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A fast and easy method for the preparation of radiolabeled 5-halo-2'-deoxyuridine (halo=[Br-76], [I-123] and [At-211]) is presented. Labeling is accomplished by oxidation of the halogenide with Iodogen for [I-123] and [At-211], and Chloramine-T (CAT) for [Br-76] followed by halodestannylation of 5-trimethylstannyl-2'-deoxyuridine (TMSUdR). The reaction takes 1 minute giving > 90% yield for all three halogens.

引用

页码：127 / 128

页数：2

共 8 条

[1] INSTANTANEOUS PREPARATION OF RADIOLABELED 5-IODO-2'-DEOXYURIDINE [J].

FOULON, CF ;

ZHANG, YZ ;

ADELSTEIN, SJ ;

KASSIS, AI .

APPLIED RADIATION AND ISOTOPES, 1995, 46 (10) :1039-1046

[2]

HARRISON K, 1994, J NUCL MED S, V35, P144

[3] SIMPLE PRODUCTION OF BR-77(-) AND I-123(-) AND THEIR USE IN THE LABELING OF [BRUDR-BR-77 AND [IUDR-I-123 [J].

LUNDQVIST, H ;

MALMBORG, P ;

LANGSTROM, B ;

CHIENGMAI, SN .

INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1979, 30 (01) :39-43

[4] SCOPE AND LIMITATIONS OF A RAPID RADIOBROMINATION TECHNIQUE [J].

MCELVANY, KD ;

WELCH, MJ ;

KATZENELLENBOGEN, JA ;

SENDEROFF, SG ;

BENTLEY, GE ;

GRANT, PM .

INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1981, 32 (06) :411-416

[5]

MEASE RC, 1990, J LABELLED COMPD RAD, V29, P393

[6]

RYSER JE, 1995, ANN REP 1995 ANN 2 P, P30

[7]

Vaidyanathan G, 1996, CANCER RES, V56, P1204

[8]

WIGERINCK P, 1994, J MED CHEM, V36, P538

← 1 →