A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice

被引：55

作者：

Peirce, JL ^{[1
]}

Derr, R ^{[1
]}

Shendure, J ^{[1
]}

Kolata, T ^{[1
]}

Silver, LM ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

MAMMALIAN GENOME | 1998年 / 9卷 / 12期

关键词：

D O I：

10.1007/s003359900904

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

C57B1/6 mice reproducibly prefer to ingest more 10% ethanol in a two-bottle choice paradigm than do DBA/2J mice. In this paper we report the identification of two new sex-specific alcohol preference (Alcp) loci. Melo and associates (1996) identified two loci: Alcp1, a male-specific locus on Chromosome (Chr) 2, and Alcp2, a female- and cross-specific locus on Chr ll. We have additionally identified Alcp3, a male-specific locus on Chr 3, and Alcp4 a female-specific locus on Chr I. We have also performed a statistical analysis to exclude the possibility of undiscovered major alcohol preference loci that are not sex-specific in our backcross paradigm. Our results indicate that alcohol preference in C57BL/6 mice, as measured in our backcross, is largely controlled in a sex-specific manner.

引用

页码：942 / 948

页数：7

共 39 条

[31]

SHEPPARD JR, 1970, J BIOL CHEM, V245, P2876

[32] ENZYME ACTIVITIES AND ETHANOL PREFERENCE IN MICE [J].

SHEPPARD, JR ;

ALBERSHEIM, P ;

MCCLEARN, GE .

BIOCHEMICAL GENETICS, 1968, 2 (03) :205-+

[33] DOES TOLERANCE DEVELOP TO THE ACTIVATING, AS WELL AS THE DEPRESSANT, EFFECTS OF ETHANOL [J].

TABAKOFF, B ;

KIIANMAA, K .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1982, 17 (05) :1073-1076

[34] High incidence of ADH2*1/ALDH2*1 genes among Japanese alcohol dependents and patients with alcoholic liver disease [J].

Tanaka, F ;

Shiratori, Y ;

Yokosuka, O ;

Imazeki, F ;

Tsukada, Y ;

Omata, M .

HEPATOLOGY, 1996, 23 (02) :234-239

[35]

Tarantino LM, 1998, ALCOHOL CLIN EXP RES, V22, P1099

[36] ALCOHOL-DEHYDROGENASE IS NOT A MAJOR DETERMINANT OF ALCOHOL PREFERENCE IN MICE [J].

TEICHERTKULISZEWSKA, K ;

ISRAEL, Y ;

CINADER, B .

ALCOHOL, 1988, 5 (01) :45-47

[37] ALCOHOL AND ALDEHYDE DEHYDROGENASE POLYMORPHISMS AND ALCOHOLISM [J].

THOMASSON, HR ;

CRABB, DW ;

EDENBERG, HJ ;

LI, TK .

BEHAVIOR GENETICS, 1993, 23 (02) :131-136

[38]

THOMASSON HR, 1991, AM J HUM GENET, V48, P677

[39] ATYPICAL LIVER ALCOHOL-DEHYDROGENASE IN THE SPANISH POPULATION - ITS RELATION WITH THE DEVELOPMENT OF ALCOHOLIC LIVER-DISEASE [J].

VIDAL, F ;

PEREZ, J ;

PANISELLO, J ;

TODA, R ;

GUTIERREZ, C ;

RICHART, C .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1993, 17 (04) :782-785

← 1 2 3 4 →