Choosing the right path: Does DNA-PK help make the decision?

被引：104

作者：

Neal, Jessica A.

Meek, Katheryn ^{[1
]}

机构：

[1] Michigan State Univ, Coll Vet Med, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2011年 / 711卷 / 1-2期

关键词：

DNA-dependent protein kinase; Non-homologous end joining; DNA double-strand break repair; DEPENDENT PROTEIN-KINASE; DOUBLE-STRAND BREAK; CLASS SWITCH RECOMBINATION; HUMAN POLYNUCLEOTIDE KINASE; BIOCHEMICALLY DEFINED SYSTEM; FIELD GEL-ELECTROPHORESIS; END-JOINING PATHWAYS; LIGASE-IV COMPLEX; CATALYTIC SUBUNIT; HOMOLOGOUS RECOMBINATION;

D O I：

10.1016/j.mrfmmm.2011.02.010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

DNA double-strand breaks are extremely harmful lesions that can lead to genomic instability and cell death if not properly repaired. There are at least three pathways that are responsible for repairing DNA double-strand breaks in mammalian cells: non-homologous end joining, homologous recombination and alternative non-homologous end joining. Here we review each of these three pathways with an emphasis on the role of the DNA-dependent protein kinase, a critical component of the non-homologous end joining pathway, in influencing which pathway is ultimately utilized for repair. (C) 2011 Elsevier B.V. All rights reserved.

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页码：73 / 86

页数：14

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