A new chiral catalytic source with an N-P=O structural framework containing a proximal hydroxyl group for the borane-mediated asymmetric reduction of prochiral ketones

被引：27

作者：

Basavaiah, D ^{[1
]}

Reddy, GJ ^{[1
]}

Chandrashekar, V ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 01期

关键词：

D O I：

10.1016/j.tetasy.2003.11.002

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(5S)-2-[(1R,2R,3S,5R)-2-Hydroxy-2,6,6-trimethylbicyclo[3. 1. 1]heptan-3-yloxy]-1,3-diaza-2-phospha-2-oxo-3-phenylbicyclo[3.3.0]octane has been successfully employed as a novel chiral catalytic source (4 mol%) for borane-mediated asymmetric reduction of prochiral ketones thus providing the resulting secondary alcohols with up to 96% enantiomeric excess. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：47 / 52

页数：6

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