Endothelium dependent and independent relaxation of aortic rings from Watanabe heritable hyperlipidemic rabbits after exposure to a free radical generating system

被引：5

作者：

Hamilton, CA ^{[1
]}

Howie, CA ^{[1
]}

Jardine, E ^{[1
]}

Reid, JL ^{[1
]}

机构：

[1] Univ Glasgow, Western Infirm, Dept Med & Therapeut, Glasgow G11 6NT, Lanark, Scotland

来源：

FREE RADICAL RESEARCH | 1998年 / 28卷 / 03期

关键词：

Watanabe heritable hyperlipidemic rabbits; free radical damage; endothelium;

D O I：

10.3109/10715769809069277

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of the xanthine oxidase/hypoxanthine free radical generating system on endothelium dependent and independent relaxation were compared in aortic rings from New Zealand white rabbits and heterozygous Watanabe heritable hyperlipidemic (WHHL) rabbits with mild atherosclerosis. Studies were carried out in young (3 months) and mature (18 months) animals. Plasma cholesterol levels were significantly higher in both 3 and 18 month WHHL animals. Endothelium independent relaxation to SNP did not differ between groups. However, the attenuation of relaxation to carbachol after xanthine oxidase/hypoxanthine treatment tended to be less in WHHL. This reached significance at 18 but not 3 months. We propose that this could be due to increases in levels of endogenous scavenger enzymes in these WHHL rabbits.

引用

页码：251 / 257

页数：7