Aurora kinases: shining lights on the therapeutic horizon?

被引：165

作者：

Andrews, PD ^{[1
]}

机构：

[1] Univ Dundee, Div Gene Regulat & Express, Wellcome Trust Bioctr, Dundee DD1 5EH, Scotland

来源：

ONCOGENE | 2005年 / 24卷 / 32期

基金：

英国惠康基金;

关键词：

aurora kinase; microtubule; spindle checkpoint; centrosome; kinetochore; therapy;

D O I：

10.1038/sj.onc.1208752

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Aurora kinases have been implicated in tumorigenesis and are important regulators of diverse cell cycle events, ranging from the entry into mitosis, centrosome function, mitotic spindle formation, chromosome biorientation and segregation, and cytokinesis. The recent identification of novel binding partners and key downstream effectors, together with new small-molecule inhibitors that display efficacy against tumours, heralds an upsurge of interest in these critical kinases. This review details new developments in the field and analyses the potential of Aurora kinases as anticancer targets.

引用

页码：5005 / 5015

页数：11

共 100 条

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