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Mitotic mechanics: the auroras come into view

被引：249
作者：
Andrews, PD [1 ]
Knatko, E [1 ]
Moore, WJ [1 ]
Swedlow, JR [1 ]
机构：
[1] Univ Dundee, Wellcome Trust Bioctr, Div Gene Express & Regulat, Dundee DD1 5EH, Scotland
来源：
CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 06期
关键词：
D O I：
10.1016/j.ceb.2003.10.013
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes. Aurora A is emerging as a critical regulator of centrosome and spindle function. Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics. This enzyme also functions in cytokinesis apparently by interacting with a critical GTPase and a kinesin-like protein. Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.
引用
收藏
页码：672 / 683
页数：12
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