Intrauterine undernutrition - renal and vascular origin of hypertension

被引：47

作者：

Franco, MD

Nigro, D

Fortes, ZB

Tostes, RCA

Carvalho, MHC

Lucas, SRR

Gomes, GN

Coimbra, TM

Gil, FZ

机构：

[1] Univ Sao Paulo, ICB 1, Dept Farmacol, Lab Hipertensao, BR-05508900 Sao Paulo, SP, Brazil

[2] Univ Fed Sao Paulo, Sao Paulo, SP, Brazil

来源：

CARDIOVASCULAR RESEARCH | 2003年 / 60卷 / 02期

关键词：

hypertension; renal function; nitric oxide; endothelial function; low birth weight;

D O I：

10.1016/S0008-6363(03)00541-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A large number of clinical and experimental studies supports the hypothesis that intrauterine undernutrition is an important determinant of hypertension, coronary heart disease and non-insulin-dependent diabetes in the adult offspring. In this review, the renal and vascular repercussions of maternal undernutrition are emphasized, and the physiopatologic mechanisms discussed. The origin of hypertension is detailed based upon the findings of kidney functional parameters and endothelium function studies. A working model linking hypertension to intrauterine undernutrition is proposed. (C) 2003 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

页码：228 / 234

页数：7

共 48 条

[21] Maternal food restriction in the second half of pregnancy affects vascular function but not blood pressure of rat female offspring [J].