Composite nano-titanium oxide-chitosan artificial skin exhibits strong wound-healing effect - An approach with anti-inflammatory and bactericidal kinetics

被引：61

作者：

Peng, Chiung-Chi ^{[2
]}

Yang, Ming-Hua ^{[1
]}

Chiu, Wen-Ta ^{[3
]}

Chiu, Chun-Hung ^{[1
]}

Yang, Chi-Shen ^{[4
]}

Chen, Yi-Wen ^{[1
]}

Chen, Kuan-Chou ^{[5
]}

Peng, Robert Y. ^{[1
,6
]}

机构：

[1] Hungkuang Univ, Dept Food & Nutr, Biotechnol Res Inst, Taichung 43302, Taiwan

[2] Cardinal Tien Coll Healthcare & Management, Dept Nursing, Sin Dian, Taipei County, Taiwan

[3] Taipei Med Univ, Dept Neurosurg, Grad Inst Injury Prevent & Control, Wang Fang Med Ctr, Taipei 110, Taiwan

[4] Hungkuang Univ, Dept Nursing, Taichung 43302, Taiwan

[5] Taipei Med Univ, Taipei Med Univ Hosp, Dept Urol, Taipei 110, Taiwan

[6] Taipei Med Univ, Coll Med, Grad Inst Med Sci, Taipei 110, Taiwan

来源：

MACROMOLECULAR BIOSCIENCE | 2008年 / 8卷 / 04期

关键词：

bactericidal (sterilization) kinetics; biodegradable; chitosan; dermis injury recovery; nano-titanium oxide;

D O I：

10.1002/mabi.200700188

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A composite nano-TiO2-chitosan with Collagen artificial skin (NTCAS) showed promising characteristics of moderate water absorptivity (110 wt.-%), fine thickness (0.34 mm), low density (0.33 mg . mm(-3)), moderate biodegradability (<3.0%), and favorable time-dependent biodegradability (0.0521 mg . mL(-1) . h(-1) on Day 0; 0.0006 mg . mL(-1) . h(-1) on Day 3 post covering). More importantly, it showed uniquely potent bactericidal (sterilization) property with relatively large values of pseudo first-order kinetic coefficients (0.1736-0.0360 min(-1)) for TiO2 contents ranging from 2.63 x 10(-5) to 2.11 x 10(-4)

引用

页码：316 / 327

页数：12

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