Expression of nicotinic acetylcholine receptor mRNA in the adult rat peripheral vestibular system

被引：71

作者：

Hiel, H

Elgoyhen, AB

Drescher, DG

Morley, BJ

机构：

[1] BOYS TOWN NATL RES HOSP, NEUROCHEM LAB, OMAHA, NE 68131 USA

[2] CONSEJO NACL INVEST CIENT & TECN, INST INVEST FARMACOL, RA-1113 BUENOS AIRES, DF, ARGENTINA

[3] WAYNE STATE UNIV, SCH MED, LAB BIOOTOL, DETROIT, MI 48201 USA

来源：

BRAIN RESEARCH | 1996年 / 738卷 / 02期

关键词：

vestibular; efferent; hybridization; in situ; hair cell; nicotinic acetylcholine receptor; Scarpa's ganglion;

D O I：

10.1016/S0006-8993(96)01046-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mRNA expression of the neuronal nicotinic acetylcholine receptor subunits was determined in adult rat vestibular end-organs and in Scarpa's ganglion (SCG) by in situ hybridization with [S-35]riboprobes. Neurons in the SCG expressed the alpha 4-7 and beta 2-3 mRNAs, but not alpha 3 or beta 4 mRNAs. Not all SCG neurons expressed every mRNA found in SCG. The alpha 6 and beta 2-3 riboprobes labeled all neurons, but alpha 4, alpha 5, and alpha 7 mRNAs were selectively expressed in one or more subpopulations of SCG neurons. Vestibular sensory hair cells, in contrast, expressed only alpha 9 mRNA.

引用

页码：347 / 352

页数：6

共 31 条

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