Small ring constrained peptidomimetics.: Synthesis of aziridine parallel β-sheet mimetics

被引：29

作者：

Filigheddu, SN ^{[1
]}

Taddei, M ^{[1
]}

机构：

[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(98)00632-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a series of novel amino acids and peptides containing an aziridine ring is described. Their preparation is based on the Gabriel-Cromwell reaction of amino acids or peptides with different 2-bromo acrylates and acrylamides. These products are constituted by a turned scaffold (the aziridine) where two parallel peptidic strands can be grown to produce a beta-sheet mimetic. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3857 / 3860

页数：4

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