Maternal Infection Requiring Hospitalization During Pregnancy and Autism Spectrum Disorders

被引：642

作者：

Atladottir, Hjordis O. ^{[1
]}

Thorsen, Poul

Ostergaard, Lars ^{[2
]}

Schendel, Diana E. ^{[3
]}

Lemcke, Sanne ^{[1
]}

Abdallah, Morsi ^{[1
]}

Parner, Erik T. ^{[4
]}

机构：

[1] Univ Aarhus, Inst Publ Hlth, Dept Epidemiol, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ Hosp, Dept Infect Dis, Res Unit Q, Skejby, Denmark

[3] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA

[4] Univ Aarhus, Inst Publ Hlth, Dept Biostat, DK-8000 Aarhus C, Denmark

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2010年 / 40卷 / 12期

关键词：

Autism spectrum disorder; Autism; Infection; Influenza; Prenatal infection; Maternal infection; BIRTH; SEASON; SCHIZOPHRENIA; ASSOCIATION; PREVALENCE; ACTIVATION; INFLUENZA; ETIOLOGY; EXPOSURE; CHILDREN;

D O I：

10.1007/s10803-010-1006-y

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Exposure to prenatal infection has been suggested to cause deficiencies in fetal neurodevelopment. In this study we included all children born in Denmark from 1980, through 2005. Diagnoses of autism spectrum disorders (ASDs) and maternal infection were obtained through nationwide registers. Data was analyzed using Cox proportional hazards regression. No association was found between any maternal infection and diagnosis of ASDs in the child when looking at the total period of pregnancy: adjusted hazard ratio = 1.14 (CI: 0.96-1.34). However, admission to hospital due to maternal viral infection in the first trimester and maternal bacterial infection in the second trimester were found to be associated with diagnosis of ASDs in the offspring, adjusted hazard ratio = 2.98 (CI: 1.29-7.15) and adjusted hazard ratio = 1.42 (CI: 1.08-1.87), respectively. Our results support prior hypotheses concerning early prenatal viral infection increasing the risk of ASDs.

引用

页码：1423 / 1430

页数：8

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