Effects of bromocriptine and/or L-DOPA on neurons in substantia nigra of MPTP-treated C57BL/6 mice

被引：16

作者：

Fukuda, T

Watabe, K

Tanaka, J

机构：

[1] Division of Neuropathology, Institute of Neuroscience, Jikei Univ. School of Medicine, Tokyo 105, 3-25-8 Nishi-shinbashi, Minato-ku

来源：

BRAIN RESEARCH | 1996年 / 728卷 / 02期

关键词：

Parkinsonism; bromocriptine; L-DOPA; C57BL/6; mouse; MPTP;

D O I：

10.1016/S0006-8993(96)00559-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of bromocriptine and/or L-DOPA on substantia nigra neurons of MPTP-intoxicated mice were investigated. L-DOPA reduced the number of neurons. Bromocriptine protected the neurons from damage by L-DOPA but had no effect on the neurons damaged by MPTP. The treatment of bromocriptine and L-DOPA protected the neurons compared with single administration of bromocriptine. It seems reasonable to suppose that bromocriptine should be added to L-DOPA in order to protect the neurons in parkinsonism.

引用

页码：274 / 276

页数：3