Pathophysiology of chronic urticaria

被引：34

作者：

Brodell, Lindsey A. ^{[1
]}

Beck, Lisa A. ^{[1
]}

Saini, Sarbjit S. ^{[2
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Dermatol, Rochester, NY 14642 USA

[2] Johns Hopkins Asthma & Allergy Ctr, Div Clin Immunol & Allergy, Baltimore, MD USA

来源：

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY | 2008年 / 100卷 / 04期

关键词：

D O I：

10.1016/S1081-1206(10)60588-1

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Objective: To review the literature on the pathogenesis of chronic urticaria (excluding physical urticaria). Data Sources: PubMed was searched using the keywords urticaria and either chronic or autoimmune of pathogenesis for articles published from January 1972 to June 2007. All searches were limited to the English language. References from review articles on chronic urticaria were also considered for inclusion in this review. Study Selection: The authors selected relevant and current sources for inclusion in this review. Results: No concise pathogenic mechanism has been identified for all cases of chronic urticaria, although evidence for a serologic mediator that may be autoimmune in nature has been identified in many cases. The activation of basophils and/or mast cells is a central feature in any theory proposed to explain this troubling disease. Conclusion: Further research is needed to better define the mechanism or mechanism(s) responsible for the development of chronic urticaria. Such research will lead to more effective and possibly even curative treatments.

引用

页码：291 / 298

页数：8

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