Biomarkers of Liver Fibrosis: What Lies Beneath the Receiver Operating Characteristic Curve?

被引：48

作者：

Guha, Indra Neil ^{[1
]}

Myers, Robert P. ^{[2
]}

Patel, Keyur ^{[3
]}

Talwalkar, Jayant A. ^{[4
]}

机构：

[1] Univ Nottingham, Liver Unit, NIHR NDDC BRU, Nottingham NG7 2UH, England

[2] Univ Calgary, Liver Unit, Calgary, AB, Canada

[3] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA

[4] Mayo Clin, Ctr Adv Imaging Res, Div Gastroenterol Hepatol, Rochester, MN USA

来源：

HEPATOLOGY | 2011年 / 54卷 / 04期

关键词：

CHRONIC HEPATITIS-C; MAGNETIC-RESONANCE ELASTOGRAPHY; DIAGNOSTIC-ACCURACY; TRANSIENT ELASTOGRAPHY; STARD STATEMENT; NONINVASIVE ASSESSMENT; CLINICAL-OUTCOMES; VIRAL-HEPATITIS; MARKER PANELS; DISEASE;

D O I：

10.1002/hep.24515

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Noninvasive biomarkers of liver fibrosis represent an intense area of research with the goals of improving patient care, disease stratification, and aiding the development of future antifibrotic therapies. Despite the rapid progress in recent years, there remain questions about how diagnostic studies are designed, statistical methods to account for spectrum bias, clinically relevant thresholds of fibrosis that should be delineated, how diagnostics can be improved, and strengthening the reference test to judge emerging biomarkers. This review discusses the current methods to address these issues and where further progress is needed. (HEPATOLOGY 2011;54:1454-1462)

引用

页码：1454 / 1462

页数：9

共 50 条

[1]

[Anonymous], 2002, NIH Consensus and State-of-the-Science Statements, V19, P1

[2] Sampling variability of liver fibrosis in chronic hepatitis C [J].