Transcription inhibition: A potential strategy for cancer therapeutics

被引：27

作者：

Derheimer, FA

Chang, CW

Ljungman, M

机构：

[1] Univ Michigan, Dept Radiat Oncol, Div Radiat & Canc Biol, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Mol & Cellular Biol Program, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA

来源：

EUROPEAN JOURNAL OF CANCER | 2005年 / 41卷 / 16期

关键词：

RNA polymerase II; p53; apoptosis; chemotherapy;

D O I：

10.1016/j.ejca.2005.08.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interference with transcription triggers a stress response leading to the induction of the tumour suppressor p53. If transcription is not restored within a certain time frame cells may undergo apoptosis in a p53-dependent and independent manner. The mechanisms by which blockage of transcription induces apoptosis may involve diminished levels of anti-apoptotic factors, inappropriate accumulation of proteins in the nucleus, accumulation of p53 at mitochondria or complications during replication. Many chemotherapeutic agents currently used in the clinic interfere with transcription and this interference may contribute to their anti-cancer activities. Future efforts should be directed towards exploring whether interference of transcription could be used as an anti-cancer therapeutic strategy. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2569 / 2576

页数：8

共 90 条

[21] The MDM2 RING-finger domain is required to promote p53 nuclear export [J].