Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani

被引：40

作者：

Amprey, JL

Späth, GF

Porcelli, SA

机构：

[1] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

[2] Cornell Univ, Weill Med Coll, New York, NY USA

[3] NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY USA

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 01期

关键词：

D O I：

10.1128/IAI.72.1.589-592.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.

引用

页码：589 / 592

页数：4

共 31 条

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