学术探索
学术期刊
新闻热点
数据分析
智能评审

Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani

被引：40
作者：
Amprey, JL
Späth, GF
Porcelli, SA
机构：
[1] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA
[2] Cornell Univ, Weill Med Coll, New York, NY USA
[3] NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY USA
来源：
INFECTION AND IMMUNITY | 2004年 / 72卷 / 01期
关键词：
D O I：
10.1128/IAI.72.1.589-592.2004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.
引用
收藏
页码：589 / 592
页数：4
相关论文
共 31 条
  • [11] CD1-specific T cells in microbial immunity
    Gumperz, JE
    Brenner, MB
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2001, 13 (04) : 471 - 478
  • [12] The development, maturation, and turnover rate of mouse spleen dendritic cell populations
    Kamath, AT
    Pooley, J
    O'Keeffe, MA
    Vremec, D
    Zhan, YF
    Lew, AM
    D'Amico, A
    Wu, L
    Tough, DF
    Shortman, K
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (12) : 6762 - 6770
  • [13] LAMPSON LA, 1980, J IMMUNOL, V125, P293
  • [14] Leenen PJM, 1998, J IMMUNOL, V160, P2166
  • [15] MCCONVILLE MJ, 1993, J BIOL CHEM, V268, P15595
  • [16] CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection
    Moody, DB
    Ulrichs, T
    Mühlecker, W
    Young, DC
    Gurcha, SS
    Grant, E
    Rosat, JP
    Brenner, MB
    Costello, CE
    Besra, GS
    Porcelli, SA
    [J]. NATURE, 2000, 404 (6780) : 884 - 888
  • [17] CD1B RESTRICTS THE RESPONSE OF HUMAN CD4-8- LYMPHOCYTES-T TO A MICROBIAL ANTIGEN
    PORCELLI, S
    MORITA, CT
    BRENNER, MB
    [J]. NATURE, 1992, 360 (6404) : 593 - 597
  • [18] PORCELLI SA, 1995, ADV IMMUNOL, V59, P1, DOI 10.1016/S0065-2776(08)60629-X
  • [19] KINETICS OF GAMMA-INTERFERON BINDING AND INDUCTION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II MESSENGER-RNA IN LEISHMANIA-INFECTED MACROPHAGES
    REINER, NE
    NG, W
    MA, T
    MCMASTER, WR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (12) : 4330 - 4334
  • [20] A MONOCLONAL-ANTIBODY BLOCKING HUMAN T-CELL FUNCTION
    REINHERZ, EL
    HUSSEY, RE
    SCHLOSSMAN, SF
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1980, 10 (10) : 758 - 762
1234