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CD1-specific T cells in microbial immunity

被引：99
作者：
Gumperz, JE
Brenner, MB
机构：
[1] Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 04期
关键词：
D O I：
10.1016/S0952-7915(00)00243-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent results strengthen evidence that CD1-restricted T cells play important roles in host defense against microbial infections. Human subjects recently infected with Mycobacterium tuberculosis showed elevated responses to CD1c-mediated presentation of a microbial lipid antigen, compared with control donors. Activation of CD1d-restricted NKT cells with a synthetic glycolipid antigen results in improved immune responses to several infectious pathogens.
引用
收藏
页码：471 / 478
页数：8
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