Mechanism of DNA damage by chromium carcinogens

被引：16

作者：

Bose, RN

Fonkeng, BS

机构：

[1] Department of Chemistry, Kent State University, Kent

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 18期

关键词：

D O I：

10.1039/cc9960002211

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oxochromium(v) centres initiate DNA cleavage through a chromium(v)phosphate diester intermediate by hydrogen abstraction from the C-1' position of the ribose sugar, leading to the formation of 5-methylene-2-furanone, 3'-phosphate terminus and DNA bases; by contrast a plasmid DNA (pUC19) is only nicked.

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页码：2211 / 2212

页数：2

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