Short report: Gametocytes, chloroquine pressure, and the relative parasite survival advantage of resistant strains of falciparum malaria in west Africa

被引:48
作者
Robert, V
Molez, JF
Trape, JF
机构
[1] Inst. Francais Rech. Sci. Devmt./C., Laboratoire de Paludologie, Dakar
[2] Laboratoire de Paludologie, ORSTOM, Dakar
关键词
D O I
10.4269/ajtmh.1996.55.350
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Patients with Plasmodium falciparum infections were selected with an in vivo chloroquine sensitivity assay. Fourteen days after treatment, the gametocytes were studied in relation to asexual parasite responses classified as drug-sensitive or showing RI or RII resistance. Gametocyte prevalence and density appeared significantly higher in RII than RI strains and higher in RI than in sensitive strains. This finding on gametocyte variation in vivo may explain why the RII type of chloroquine resistance has became more prevalent than RI everywhere in tropical Africa in the short time since its emergence. The biological and epidemiologic advantage of chloroquine-resistant malaria mediated through gametocytes is discussed in the context of the present drug pressure in Africa.
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收藏
页码:350 / 351
页数:2
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