Angiotensin receptors: a new role in cancer?

被引：370

作者：

Deshayes, F ^{[1
]}

Nahmias, C ^{[1
]}

机构：

[1] Inst Cochin, CNRS,UMR 8104, INSERM,U567, Dept Biol Cellulaire, F-75014 Paris, France

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2005年 / 16卷 / 07期

关键词：

D O I：

10.1016/j.tem.2005.07.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is increasing evidence that Angiotensin II (AngII), a major regulator of blood pressure and cardiovascular homeostasis, is involved in the regulation of cell proliferation, angiogenesis, inflammation and tissue remodeling, which suggests that this peptide might also play a role in cancer. This review focuses on the expression and function of Angiotensin I-converting enzyme (ACE) and AngII receptors in various aspects of cancer. Recent experimental data suggests that ACE inhibitors and AngII type 1 receptor (AT1R) antagonists have beneficial effects on tumor progression, vascularization and metastasis, and that the AngII type 2 receptor (AT2R) subtype has a potential role in cancer. An overview of the major intracellular signaling pathways associated with AT1R and AT2R activation in cancer cells, as well as in endothelial and inflammatory cells, is presented here.

引用

页码：293 / 299

页数：7

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