Broken asymmetry of the human heartbeat: Loss of time irreversibility in aging and disease

被引:201
作者
Costa, M [1 ]
Goldberger, AL
Peng, CK
机构
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Cardiovasc, Boston, MA 02215 USA
[2] Univ Lisbon, Fac Sci, Inst Biophys & Biomed Engn, P-1749016 Lisbon, Portugal
关键词
D O I
10.1103/PhysRevLett.95.198102
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
Time irreversibility, a fundamental property of nonequilibrium systems, should be of importance in assessing the status of physiological processes that operate over a wide range of scales. However, measurement of this property in living systems has been limited. We provide a computational method derived from basic physics assumptions to quantify time asymmetry over multiple scales and apply it to the human heartbeat time series in health and disease. We find that the multiscale time asymmetry index is highest for a time series from young subjects and decreases with aging or heart disease. Loss of time irreversibility may provide a new way of assessing the functionality of living systems that operate far from equilibrium.
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页数:4
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