Role of Fe Doping in Tuning the Band Gap of TiO2 for the Photo-Oxidation-Induced Cytotoxicity Paradigm

被引：372

作者：

George, Saji ^{[2
,3
]}

Pokhrel, Suman ^{[1
]}

Ji, Zhaoxia ^{[4
]}

Henderson, Bryana L. ^{[4
]}

Xia, Tian ^{[2
,3
]}

Li, LinJiang ^{[2
,3
]}

Zink, Jeffrey I. ^{[4
]}

Nel, Andre E. ^{[2
,3
]}

Maedler, Lutz ^{[1
,3
]}

机构：

[1] Univ Bremen, Dept Prod Engn, Fdn Inst Mat Sci IWT, D-2800 Bremen 33, Germany

[2] Univ Calif Los Angeles, Dept Med, Div NanoMed, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90024 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 29期

基金：

美国国家科学基金会;

关键词：

TITANIUM-DIOXIDE; PHOTOCATALYTIC ACTIVITY; OXIDE NANOPARTICLES; ULTRAFINE TIO2; ZINC-OXIDE; LIGHT; MECHANISMS; PARTICLES; EVOLUTION; TOXICITY;

D O I：

10.1021/ja202836s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

UV-light-induced electron-hole (e(-)/h(+)) pair generation with free radical production in TiO2-based nanoparticles is a major conceptual paradigm for biological injury. However, to date, this hypothesis has been difficult to experimentally verify due to the high energy of UV light that is intrinsically highly toxic to biological systems. Here, a versatile flame spray pyrolysis (FSP) synthetic process has been exploited to synthesize a library of iron-doped (0-10 wt%) TiO2 nanoparticles. These particles have been tested for photoactivation-mediated cytotoxicity using near-visible light exposure. The reduction in TiO2 band gap energy with incremental levels of Fe loading maintained the nanoparticle crystalline structure in spite of homogeneous Fe distribution (demonstrated by XRD, HRTEM, SAED, EFTEM, and EELS). Photochemical studies showed that band gap energy was reciprocally tuned proportional to the Fe content. The photo-oxidation capability of Fe-doped TiO2 was found to increase during near-visible light exposure. Use of a macrophage cell line to evaluate cytotoxic and ROS production showed increased oxidant injury and cell death in parallel with a decrease in band gap energy. These findings demonstrate the importance of band gap energy in the phototoxic response of the cell to TiO2 nanoparticles and reflect the potential of this material to generate adverse effects in humans and the environment during high-intensity light exposure.

引用

页码：11270 / 11278

页数：9

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