Plant-derived compounds in clinical trials

被引:335
作者
Saklani, Arvind [1 ]
Kutty, Samuel K. [1 ]
机构
[1] Natl Inst Pharmaceut Educ & Res, Dept Nat Prod, SAS Nagar 160062, Punjab, India
关键词
D O I
10.1016/j.drudis.2007.10.010
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Plants remain an important source of new drugs, new drug leads and new chemical entities. The plant-based drug discovery resulted mainly in the development of anticancer and anti-infectious agents and continues to contribute to the new leads in clinical trials. A total of 91 plant-derived compounds in clinical trials as of September 2007 are described in this review. A summary of the plant-based drugs launched during 2000-2006 is given.
引用
收藏
页码:161 / 171
页数:11
相关论文
共 42 条
[1]   From Chinese medicine to anticancer drugs [J].
Bradbury, J .
DRUG DISCOVERY TODAY, 2005, 10 (17) :1131-1132
[2]   The role of natural product chemistry in drug discovery [J].
Butler, MS .
JOURNAL OF NATURAL PRODUCTS, 2004, 67 (12) :2141-2153
[3]  
Butler MS, 2005, NAT PROD REP, V22, P162, DOI 10.1039/b402985m
[4]  
Camps P, 2002, MINI-REV MED CHEM, V2, P12
[5]   Challenges and opportunities confronting the botanical dietary supplement industry [J].
Cardellina, JH .
JOURNAL OF NATURAL PRODUCTS, 2002, 65 (07) :1073-1084
[6]   Drug discovery from natural sources [J].
Chin, Young-Won ;
Balunas, Marcy J. ;
Chai, Hee Byung ;
Kinghorn, A. Douglas .
AAPS JOURNAL, 2006, 8 (02) :E239-E253
[7]   Lessons from natural molecules [J].
Clardy, J ;
Walsh, C .
NATURE, 2004, 432 (7019) :829-837
[8]   LC-NMR-MS in drug discovery [J].
Corcoran, O ;
Spraul, M .
DRUG DISCOVERY TODAY, 2003, 8 (14) :624-631
[9]   A tale of two tumor targets: Topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy [J].
Cragg, GM ;
Newman, DJ .
JOURNAL OF NATURAL PRODUCTS, 2004, 67 (02) :232-244
[10]   NEGATIVELY STAINED VINBLASTINE AGGREGATES [J].
ERICKSON, HP .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1975, 253 (JUN30) :51-52