Early self-experienced neuropsychological deficits and subsequent schizophrenic diseases: An 8-year average follow-up prospective study

被引:95
作者
Klosterkotter, J [1 ]
SchultzeLutter, F [1 ]
Gross, G [1 ]
Huber, G [1 ]
Steinmeyer, EM [1 ]
机构
[1] UNIV BONN,PSYCHIAT CLIN,D-5300 BONN,GERMANY
关键词
schizophrenia; psychosis; neuropsychological deficits;
D O I
10.1111/j.1600-0447.1997.tb09652.x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The aim of the present study was to investigate the potential predictive value of early self-experienced neuropsychological deficits for the subsequent development of schizophrenia. A total of 96 patients with DSM-III-R diagnoses of personality disorders (formerly called 'neurotic disorders') who had been examined for the presence of such subjective experiences of deficits with standardized instruments were re-examined for the possible development of schizophrenic symptoms. After an average follow-up period of about 8 years, more than 50% of the patients had developed schizophrenia according to DSM-III-R criteria. In 77% of cases the outcome 'schizophrenia vs, no schizophrenia' was correctly predicted by the earlier presence or absence of self-experienced disturbances of thought, speech, memory, perception and action. These findings suggest that certain self-experienced neuropsychological deficits are able to indicate susceptibility to psychosis.
引用
收藏
页码:396 / 404
页数:9
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