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Lactococcus lactis-based vaccines from laboratory bench to human use: An overview

被引：53
作者：
Bahey-El-Din, Mohammed [1 ]
机构：
[1] Univ Alexandria, Fac Pharm, Dept Pharmaceut Microbiol, Alexandria, Egypt
来源：
VACCINE | 2012年 / 30卷 / 04期
关键词：
Lactococcus lactis; Mucosal vaccine; Delivery system; Biological containment; GEM; Mimopath; MULTI-PARTICULATE FORMULATION; SYSTEMIC IMMUNE-RESPONSES; MUCOSAL DELIVERY; LISTERIA-MONOCYTOGENES; NEUTRALIZING ANTIBODIES; BIOLOGICAL CONTAINMENT; ORAL VACCINATION; GEM PARTICLES; E7; ANTIGEN; PROTECTION;
D O I：
10.1016/j.vaccine.2011.11.098
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Developing effective vaccines is an important weapon in the battle against potential pathogens and their evolving antibiotic resistance trends. Several vaccine delivery vectors have been investigated among which the generally regarded as safe (GRAS) Lactococcus lactis has a distinguished position. In this review, different factors affecting the efficacy of L. lactis-based vaccines are discussed. In addition, the issues of biological containment and pharmaceutical quality assurance of L. lactis vaccines are highlighted. These issues are critical for the success of medical translation of L. lactis-based vaccines from research laboratories to clinical use by ensuring consistent manufacturing of safe and efficacious vaccines. (C) 2011 Elsevier Ltd. All rights reserved.
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页码：685 / 690
页数：6
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