Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity

被引：31

作者：

Rainio, EM

Ahlfors, H

Carter, KL

Ruuska, M

Matikainen, S

Kieff, E

Koskinen, PJ

机构：

[1] Turku Univ, Abo Akad Univ, Turku Ctr Biotechnol, Turku 20520, Finland

[2] Harvard Univ, Sch Med, Dept Med & Microbiol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Mol Genet, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA

[5] Natl Publ Hlth Inst, Dept Microbiol, SF-00300 Helsinki, Finland

[6] Turku Grad Sch Biomed Sci, Turku 20520, Finland

来源：

VIROLOGY | 2005年 / 333卷 / 02期

关键词：

EBV; EBNA2; Pim; transcription;

D O I：

10.1016/j.virol.2005.01.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Latent Epstein-Barr virus (EBV) infection is strongly associated with B-cell proliferative diseases such as Burkitt's lymphoma. Here we show that the oncogenic serine/threonine kinases Pim-1 and Pim-2 enhance the activity of the viral transcriptional activator EBNA2. During EBV infection of primary B-lymphocytes, the mRNA expression levels of pint genes, especially of pim-2, are upregulated and remain elevated in latently infected B-cell lines. Thus, EBV-induced upregulation of Pim kinases and Pim-stimulated EBNA2 transcriptional activity may contribute to the ability of EBV to immortalize B-cells and predispose them to malignant growth. (C) 2005 Elsevier Inc. All rights reserved.

引用

收藏

页码：201 / 206

页数：6

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