High performance liquid chromatographic determination of 123-I labeled tamoxifen metabolites in human plasma

被引：4

作者：

De Vos, F

Van de Wiele, C

Vandecapelle, M

Dierckx, RA

Slegers, G

机构：

[1] Univ Hosp Gent, Div Nucl Med, B-9000 Ghent, Belgium

[2] State Univ Ghent, Dept Radiopharm, B-9000 Ghent, Belgium

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2001年 / 28卷 / 03期

关键词：

tamoxifen; metabolites; I-123;

D O I：

10.1016/S0969-8051(01)00195-0

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A high-performance liquid chromatographic procedure for the quantitation of [I-123]Iodomethyl-N, N-diethyltamoxifen (ITX), a radioligand for human breast cancer imaging, in human plasma is described. Separation was effected on a RP-C18 column, using a mixture of acetonitrile-water-triethylamine (70/30/0.5, v/v). ITX was rapidly cleared from human plasma and metabolites appeared as early as 7.5 min p.i. Quantitative assessment of metabolites in plasma over time allowed recalculation of the ITX plasma time-activity curve. Implications of ITX metabolite formation for breast tumour imaging are discussed. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：335 / 338

页数：4

共 10 条

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[2]

Dickson Robert B., 1997, P1541

[3] MECHANISMS OF HORMONE RESISTANCE IN BREAST-CANCER [J].