Enhanced anti-cancer activities of some derivatives of titanocene dichloride

被引：64

作者：

Boyles, JR

Baird, MC ^{[1
]}

Campling, BG

Jain, N

机构：

[1] Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada

[2] Queens Univ, Canc Res Lab, Kingston, ON K7L 3N6, Canada

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2001年 / 84卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

titanocene dichloride; anti-cancer drugs; metallocenes;

D O I：

10.1016/S0162-0134(00)00203-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The compounds (eta (5)-C5H5)(2)TiCl2 (I), currently undergoing phase II trials, (eta (5)-C5H5)(eta (5)-C5H4CO2Me)TiCl2 (II) and (eta (5)- C5H4CO2Me)(2)TiCl2 (III) are assessed for their efficacies against a small lung cancer cell line. It is found that the introduction of the electron withdrawing carbomethoxy group into the cyclopentadienyl rings increases the effectiveness of this class of drugs, such that III compares favorably with the well known cisplatin. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：159 / 162

页数：4

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