Antiinflammatory 4,5-diarylimidazoles as selective cyclooxygenase inhibitors

被引：61

作者：

Barta, TE ^{[1
]}

Stealey, MA ^{[1
]}

Collins, PW ^{[1
]}

Weier, RM ^{[1
]}

机构：

[1] GD Searle & Co, Skokie, IL 60077 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(98)00627-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and activity of a series of 4,5-diarylimidazole analogs are described. One analog had an IC50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3443 / 3448

页数：6

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