Antiinflammatory 4,5-diarylimidazoles as selective cyclooxygenase inhibitors

被引:61
作者
Barta, TE [1 ]
Stealey, MA [1 ]
Collins, PW [1 ]
Weier, RM [1 ]
机构
[1] GD Searle & Co, Skokie, IL 60077 USA
关键词
D O I
10.1016/S0960-894X(98)00627-1
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The synthesis and activity of a series of 4,5-diarylimidazole analogs are described. One analog had an IC50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码:3443 / 3448
页数:6
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