Quantum mechanical/molecular mechanical studies on spectral tuning mechanisms of visual pigments and other photoactive proteins

被引：31

作者：

Altun, Ahmet ^{[2
,3
]}

Yokoyama, Shozo ^{[1
]}

Morokuma, Keiji ^{[2
,3
,4
]}

机构：

[1] Emory Univ, Dept Biol, Rollins Res Ctr, Atlanta, GA 30322 USA

[2] Emory Univ, Cherry L Emerson Ctr Sci Computat, Atlanta, GA 30322 USA

[3] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

[4] Kyoto Univ, Fukui Inst Fundamental Chem, Kyoto, Japan

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 2008年 / 84卷 / 04期

关键词：

D O I：

10.1111/j.1751-1097.2008.00308.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protein environments surrounding the retinal tune electronic absorption maximum from 350 to 630 nm. Hybrid quantum mechanical/molecular mechanical (QM/MM) methods can be used in calculating excitation energies of retinal in its native protein environments and in studying the molecular basis of spectral tuning. We hereby review recent QM/MM results on the phototransduction of bovine rhodopsin, bacteriorhodopsin, sensory rhodopsin II, nonretinal photoactive yellow protein and their mutants.

引用

收藏

页码：845 / 854

页数：10

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