Antimicrobial activity of viridiofungins

被引：31

作者：

Onishi, JC

Milligan, JA

Basilio, A

Bergstrom, J

Curotto, J

Huang, L

Meinz, M

NallinOmstead, M

Pelaez, F

Rew, D

Salvatore, M

Thompson, J

Vicente, F

Kurtz, MB

机构：

[1] Merck Res. Laboratories, R80Y-225, Rahway, NJ 07065-0900

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 04期

关键词：

D O I：

10.7164/antibiotics.50.334

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A family of aminoacyl alkyl citrate compounds called viridiofungins, are novel squalene synthase inhibitors. The compounds have broad spectrum fungicidal activity but lack antibacterial activity. Although the compounds inhibit squalene synthase, the first committed step in ergosterol biosynthesis, results presented in this paper show that inhibition of fungal growth is not related to inhibition of ergosterol synthesis.

引用

页码：334 / 338

页数：5

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