Embryonic stem cell therapy for diabetes mellitus

被引：33

作者：

Docherty, Kevin ^{[1
]}

Bernardo, Andreia S. ^{[1
]}

Vallier, Ludovic ^{[2
,3
]}

机构：

[1] Univ Aberdeen, Sch Med Sci, Inst Med Sci, Aberdeen AB25 2ZD, Scotland

[2] Univ Cambridge, Addenbrookes Hosp, Dept Surg, Cambridge CB2 0XY, England

[3] Univ Cambridge, Addenbrookes Hosp, Cambridge Inst Med Res, Cambridge CB2 0XY, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 06期

基金：

英国惠康基金;

关键词：

differentiation; Pdx1; insulin gene; regenerative medicine; cell therapy; pancreas development;

D O I：

10.1016/j.semcdb.2007.09.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There is a compelling need to develop novel therapies for diabetes mellitus. Recent successes in the transplantation of islets of Langerhans are seen as a major breakthrough. However, there is huge disparity between potential recipients and the availability of donor tissue. Human embryonic stem cells induced to form pancreatic beta cells could provide a replenishable supply of tissue. Early studies on the spontaneous differentiation of mouse embryonic stem cells have laid the foundation for a more directed approach based on recapitulating the events that occur during the development of the pancreas in the mouse. A high yield of definitive endoderm has been achieved, and although beta-like cells can be generated in a step-wise manner, the efficiency is still low and the final product is not fully differentiated. Future challenges include generating fully functional islet cells under Xeno-free and chemically defined conditions and circumventing the need for immunosuppression. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：827 / 838

页数：12

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