Embryonic stem cell therapy for diabetes mellitus

被引：33

作者：

Docherty, Kevin ^{[1
]}

Bernardo, Andreia S. ^{[1
]}

Vallier, Ludovic ^{[2
,3
]}

机构：

[1] Univ Aberdeen, Sch Med Sci, Inst Med Sci, Aberdeen AB25 2ZD, Scotland

[2] Univ Cambridge, Addenbrookes Hosp, Dept Surg, Cambridge CB2 0XY, England

[3] Univ Cambridge, Addenbrookes Hosp, Cambridge Inst Med Res, Cambridge CB2 0XY, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 06期

基金：

英国惠康基金;

关键词：

differentiation; Pdx1; insulin gene; regenerative medicine; cell therapy; pancreas development;

D O I：

10.1016/j.semcdb.2007.09.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There is a compelling need to develop novel therapies for diabetes mellitus. Recent successes in the transplantation of islets of Langerhans are seen as a major breakthrough. However, there is huge disparity between potential recipients and the availability of donor tissue. Human embryonic stem cells induced to form pancreatic beta cells could provide a replenishable supply of tissue. Early studies on the spontaneous differentiation of mouse embryonic stem cells have laid the foundation for a more directed approach based on recapitulating the events that occur during the development of the pancreas in the mouse. A high yield of definitive endoderm has been achieved, and although beta-like cells can be generated in a step-wise manner, the efficiency is still low and the final product is not fully differentiated. Future challenges include generating fully functional islet cells under Xeno-free and chemically defined conditions and circumventing the need for immunosuppression. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：827 / 838

页数：12

共 141 条

[41] neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas [J].

Gradwohl, G ;

Dierich, A ;

LeMeur, M ;

Guillemot, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) :1607-1611

[42] Endoderm development - from patterning to organogenesis [J].

Grapin-Botton, A ;

Melton, DA .

TRENDS IN GENETICS, 2000, 16 (03) :124-130

[43] Gene and cell-replacement therapy in the treatment of type 1 diabetes -: How high must the standards be set? [J].

Halban, PA ;

Kahn, SE ;

Lernmark, Å ;

Rhodes, CJ .

DIABETES, 2001, 50 (10) :2181-2191

[44]

Han Z, 2007, CURR OPIN MOL THER, V9, P392

[45] Artifactual insulin release from differentiated embryonic stem cells [J].

Hansson, M ;

Tonning, A ;

Frandsen, U ;

Petri, A ;

Rajagopal, J ;

England, MCO ;

Heller, RS ;

Håkansson, J ;

Fleckner, J ;

Sköld HN ;

Melton, D ;

Semb, H ;

Serup, P .

DIABETES, 2004, 53 (10) :2603-2609

[46] Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice [J].

Harrison, KA ;

Thaler, J ;

Pfaff, SL ;

Gu, H ;

Kehrl, JH .

NATURE GENETICS, 1999, 23 (01) :71-75

[47] Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells [J].

Hart, A ;

Papadopoulou, S ;

Edlund, H .

DEVELOPMENTAL DYNAMICS, 2003, 228 (02) :185-193

[48] Comparative analysis of insulin gene promoters - Implications for diabetes research [J].

Hay, Colin W. ;

Docherty, Kevin .

DIABETES, 2006, 55 (12) :3201-3213

[49] Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells [J].

Hori, Y ;

Rulifson, IC ;

Tsai, BC ;

Heit, JJ ;

Cahoy, JD ;

Kim, SK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (25) :16105-16110

[50] HNF-6-independent differentiation of mouse embryonic stem cells into insulin-producing cells [J].

Houard, N ;

Rousseau, GG ;

Lemaigre, FP .

DIABETOLOGIA, 2003, 46 (03) :378-385

← 1 2 3 4 5 6 7 8 9 10 →