Intercalation of oganic dye molecules into double-stranded DNA. Part 2: The annelated quinolizinium ion as a structural motif in DNA intercalators

被引:103
作者
Ihmels, H
Faulhaber, K
Vedaldi, D
Dall'Acqua, F
Viola, G
机构
[1] Univ Siegen, Inst Organ Chem, D-57068 Siegen, Germany
[2] Univ Wurzburg, Inst Organ Chem, Wurzburg, Germany
[3] Univ Padua, Dept Pharmaceut Sci, Padua, Italy
关键词
D O I
10.1562/2005-01-25-IR-427
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
DNA intercalators represent an important class of compounds with a high potential as DNA-targeting drugs. In this review it is demonstrated that annelated quinolizinium derivatives such as coralyne and derivatives thereof intercalate into DNA and that this structural motif allows several variations of the substitution pattern without loss of intercalating properties. The commonly applied methods for the evaluation of the DNA association, mainly spectroscopic studies, are pointed out. In addition, studies on the biological activities of annelated quinolizinium derivatives, such as topoisomerase poisoning or cell toxicity, are highlighted.
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页码:1107 / 1115
页数:9
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