共 161 条
Transposon-based strategies for microbial functional genomics and proteomics
被引:121
作者:

Hayes, F
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Manchester, Inst Sci & Technol, Dept Biomol Sci, Manchester M60 1QD, Lancs, England Univ Manchester, Inst Sci & Technol, Dept Biomol Sci, Manchester M60 1QD, Lancs, England
机构:
[1] Univ Manchester, Inst Sci & Technol, Dept Biomol Sci, Manchester M60 1QD, Lancs, England
关键词:
transposon;
mutagenesis;
bacteria;
pentapeptide scanning;
signature-tagged mutagenesis;
D O I:
10.1146/annurev.genet.37.110801.142807
中图分类号:
Q3 [遗传学];
学科分类号:
071007 ;
090102 ;
摘要:
Transposons are mobile genetic elements that can relocate from one genomic location to another. As well as modulating gene expression and contributing to genome plasticity and evolution, transposons are remarkably diverse molecular tools for both whole-genome and single-gene studies in bacteria, yeast, and other microorganisms. Efficient but simple in vitro transposition reactions now allow the mutational analysis of previously recalcitrant microorganisms. Transposon-based signature tagged mutagenesis and genetic footprinting strategies have pinpointed essential genes and genes that are crucial for the infectivity of a variety of human and other pathogens. Individual proteins and protein complexes can be dissected by transposon-mediated scanning linker mutagenesis. These and other transposon-based approaches have reaffirmed the usefulness of these elements as simple yet highly effective mutagens for both functional genomic and proteomic studies of microorganisms.
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页码:3 / 29
页数:27
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共 161 条
[1]
Establishment of uncharacterized plasmids in Escherichia coli by in vitro transposition
[J].
Agron, PG
;
Sobecky, P
;
Andersen, GL
.
FEMS MICROBIOLOGY LETTERS,
2002, 217 (02)
:249-254

Agron, PG
论文数: 0 引用数: 0
h-index: 0
机构: Lawrence Livermore Natl Lab, Biol & Biotechnol Res Program, Livermore, CA 94550 USA

Sobecky, P
论文数: 0 引用数: 0
h-index: 0
机构: Lawrence Livermore Natl Lab, Biol & Biotechnol Res Program, Livermore, CA 94550 USA

Andersen, GL
论文数: 0 引用数: 0
h-index: 0
机构: Lawrence Livermore Natl Lab, Biol & Biotechnol Res Program, Livermore, CA 94550 USA
[2]
A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae
[J].
Akerley, BJ
;
Rubin, EJ
;
Novick, VL
;
Amaya, K
;
Judson, N
;
Mekalanos, JJ
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2002, 99 (02)
:966-971

Akerley, BJ
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

Rubin, EJ
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

Novick, VL
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

Amaya, K
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

Judson, N
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

Mekalanos, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA
[3]
Systematic identification of essential genes by in vitro mariner mutagenesis
[J].
Akerley, BJ
;
Rubin, EJ
;
Camilli, A
;
Lampe, DJ
;
Robertson, HM
;
Mekalanos, JJ
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1998, 95 (15)
:8927-8932

Akerley, BJ
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

Rubin, EJ
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

Camilli, A
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

Lampe, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

Robertson, HM
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

Mekalanos, JJ
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA
[4]
Transposable dual reporters for studying the structure-function relationships in membrane proteins:: Permissive sites R-prowazekii ATP/ADP translocase
[J].
Alexeyev, MF
;
Winkler, HH
.
BIOCHEMISTRY,
2002, 41 (01)
:406-414

Alexeyev, MF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ S Alabama, Coll Med, Dept Microbiol & Immunol, Mol Biol Lab, Mobile, AL 36688 USA Univ S Alabama, Coll Med, Dept Microbiol & Immunol, Mol Biol Lab, Mobile, AL 36688 USA

Winkler, HH
论文数: 0 引用数: 0
h-index: 0
机构:
Univ S Alabama, Coll Med, Dept Microbiol & Immunol, Mol Biol Lab, Mobile, AL 36688 USA Univ S Alabama, Coll Med, Dept Microbiol & Immunol, Mol Biol Lab, Mobile, AL 36688 USA
[5]
Identification of new genes involved in the virulence of Listeria monocytogenes by signature-tagged transposon mutagenesis
[J].
Autret, N
;
Dubail, I
;
Trieu-Cuot, P
;
Berche, P
;
Charbit, A
.
INFECTION AND IMMUNITY,
2001, 69 (04)
:2054-2065

Autret, N
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Necker Enfants Malad, INSERM, U411, F-75730 Paris 15, France CHU Necker Enfants Malad, INSERM, U411, F-75730 Paris 15, France

Dubail, I
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Necker Enfants Malad, INSERM, U411, F-75730 Paris 15, France CHU Necker Enfants Malad, INSERM, U411, F-75730 Paris 15, France

Trieu-Cuot, P
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Necker Enfants Malad, INSERM, U411, F-75730 Paris 15, France CHU Necker Enfants Malad, INSERM, U411, F-75730 Paris 15, France

Berche, P
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Necker Enfants Malad, INSERM, U411, F-75730 Paris 15, France CHU Necker Enfants Malad, INSERM, U411, F-75730 Paris 15, France

Charbit, A
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Necker Enfants Malad, INSERM, U411, F-75730 Paris 15, France CHU Necker Enfants Malad, INSERM, U411, F-75730 Paris 15, France
[6]
Escherichia coli genes regulated by cell-to-cell signaling
[J].
Baca-DeLancey, RR
;
South, MMT
;
Ding, XD
;
Rather, PN
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1999, 96 (08)
:4610-4614

Baca-DeLancey, RR
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Sch Med, Div Infect Dis, Dept Med, Cleveland, OH 44106 USA

South, MMT
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Sch Med, Div Infect Dis, Dept Med, Cleveland, OH 44106 USA

Ding, XD
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Sch Med, Div Infect Dis, Dept Med, Cleveland, OH 44106 USA

Rather, PN
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Sch Med, Div Infect Dis, Dept Med, Cleveland, OH 44106 USA
[7]
Selection analyses of insertional mutants using subgenic-resolution arrays
[J].
Badarinarayana, V
;
Estep, PW
;
Shendure, J
;
Edwards, J
;
Tavazoie, S
;
Lam, F
;
Church, GM
.
NATURE BIOTECHNOLOGY,
2001, 19 (11)
:1060-1065

Badarinarayana, V
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

Estep, PW
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

Shendure, J
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

Edwards, J
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

Tavazoie, S
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

Lam, F
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

Church, GM
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
[8]
Application of signature-tagged mutagenesis for identification of Escherichia coli K1 genes that contribute to invasion of human brain microvascular endothelial cells
[J].
Badger, JL
;
Wass, CA
;
Weissman, SJ
;
Kim, KS
.
INFECTION AND IMMUNITY,
2000, 68 (09)
:5056-5061

Badger, JL
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Hosp Los Angeles, Div Infect Dis, Los Angeles, CA 90027 USA

Wass, CA
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Hosp Los Angeles, Div Infect Dis, Los Angeles, CA 90027 USA

Weissman, SJ
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Hosp Los Angeles, Div Infect Dis, Los Angeles, CA 90027 USA

Kim, KS
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Hosp Los Angeles, Div Infect Dis, Los Angeles, CA 90027 USA
[9]
Genome-wide internal tagging of bacterial exported proteins
[J].
Bailey, J
;
Manoil, C
.
NATURE BIOTECHNOLOGY,
2002, 20 (08)
:839-842

Bailey, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

Manoil, C
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
[10]
TN7 TRANSPOSITION - TARGET DNA RECOGNITION IS MEDIATED BY MULTIPLE TN7-ENCODED PROTEINS IN A PURIFIED INVITRO SYSTEM
[J].
BAINTON, RJ
;
KUBO, KM
;
FENG, JN
;
CRAIG, NL
.
CELL,
1993, 72 (06)
:931-943

BAINTON, RJ
论文数: 0 引用数: 0
h-index: 0
机构:
JOHNS HOPKINS UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT MOLEC BIOL & GENET, BALTIMORE, MD 21205 USA JOHNS HOPKINS UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT MOLEC BIOL & GENET, BALTIMORE, MD 21205 USA

KUBO, KM
论文数: 0 引用数: 0
h-index: 0
机构:
JOHNS HOPKINS UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT MOLEC BIOL & GENET, BALTIMORE, MD 21205 USA JOHNS HOPKINS UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT MOLEC BIOL & GENET, BALTIMORE, MD 21205 USA

FENG, JN
论文数: 0 引用数: 0
h-index: 0
机构:
JOHNS HOPKINS UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT MOLEC BIOL & GENET, BALTIMORE, MD 21205 USA JOHNS HOPKINS UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT MOLEC BIOL & GENET, BALTIMORE, MD 21205 USA

CRAIG, NL
论文数: 0 引用数: 0
h-index: 0
机构:
JOHNS HOPKINS UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT MOLEC BIOL & GENET, BALTIMORE, MD 21205 USA JOHNS HOPKINS UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT MOLEC BIOL & GENET, BALTIMORE, MD 21205 USA