RNA binding proteins and selenocysteine

被引：22

作者：

Copeland, PR ^{[1
]}

Driscoll, DM ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Dept Cell Biol, Lerner Res Inst, Cleveland, OH 44195 USA

来源：

BIOFACTORS | 2001年 / 14卷 / 1-4期

关键词：

selenoprotein biosynthesis; eukarya; selenocysteine insertion; SECIS; SBP2; EFSec;

D O I：

10.1002/biof.5520140103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Selenocysteine is incorporated into protein by a complex co-translational mechanism that involves both cis and trans acting factors. Among the trans-acting factors are RNA binding proteins that interact with the selenoprotein 3' UTRs at a sequence known as the selenocysteine insertion sequence (SECTS). These factors are generally referred to as SBPs, and in this review we will discuss the history of the SBPs, and give a detailed description of the recently identified SBP2 which is the only SBP known to be required for See insertion. The mechanism by which SBP2 may be involved in this process will be discussed.

引用

页码：11 / 16

页数：6

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