New cancer susceptibility loci:: Population and familial risks

被引：14

作者：

Hemminki, Kari ^{[1
,2
]}

Forsti, Asta ^{[1
,2
]}

Bermejo, Justo Lorenzo ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Mol Genet Epidemiol, D-69120 Heidelberg, Germany

[2] Karolinska Inst, Ctr Family & Community Med, Huddinge, Sweden

来源：

INTERNATIONAL JOURNAL OF CANCER | 2008年 / 123卷 / 07期

关键词：

familial risk; population attributable fraction; genotype relative risk; cancer genetics;

D O I：

10.1002/ijc.23702

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The recent large genotyping studies have identified a new repertoire of cancer susceptibility genes and loci which are characterized by common risk alleles and low relative risks. Because or these properties, these loci explain a much larger proportion of the etiology of the particular cancers, described by the population attributable fraction (PAF), than of their familial risks (FRRs). For breast cancer, the 9 established loci gave a joint PAF or >60%, but explaining only some 8% or the empirical FRR. For prostate cancer, 6 indepenent loci at chromosome 8q conferred a joint PAF of 35% but the loci explained no more than 1.9% of the empirical excess familial risks. For colorectal cancer, the contributions of the 2 identified loci to PAF and FRR were somewhat lower. The genome-wide array platforms have been built for common variants, constraining the results to variants with high PAFs and low FRRs. However, the common variants are likely to tag rarer causative variants with much higher FRRs. The detected loci are noncoding and the underlying genetic mechanisms have not been worked out. The data suggest, in spite of the reservations for combining data on PAFs across populations, that the published first-generation genome-wide scans on breast, prostate and colorectal cancers have made successful inroads into genomics or common cancers, yet leaving the mechanisms to be explained. (C) 2008 Wiley-Liss, Inc.

引用

页码：1726 / 1729

页数：4

共 28 条

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Altshuler, D ;

Brooks, LD ;

Chakravarti, A ;

Collins, FS ;

Daly, MJ ;

Donnelly, P ;

Gibbs, RA ;

Belmont, JW ;

Boudreau, A ;

Leal, SM ;

Hardenbol, P ;

Pasternak, S ;

Wheeler, DA ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Zeng, CQ ;

Gao, Y ;

Hu, HR ;

Hu, WT ;

Li, CH ;

Lin, W ;

Liu, SQ ;

Pan, H ;

Tang, XL ;

Wang, J ;

Wang, W ;

Yu, J ;

Zhang, B ;

Zhang, QR ;

Zhao, HB ;

Zhao, H ;

Zhou, J ;

Gabriel, SB ;

Barry, R ;

Blumenstiel, B ;

Camargo, A ;

Defelice, M ;

Faggart, M ;

Goyette, M ;

Gupta, S ;

Moore, J ;

Nguyen, H ;

Onofrio, RC ;

Parkin, M ;

Roy, J ;

Stahl, E ;

Winchester, E ;

Ziaugra, L ;

Shen, Y .

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Broderick, Peter ;

Carvajal-Carmona, Luis ;

Pittman, Alan M. ;

Webb, Emily ;

Howarth, Kimberley ;

Rowan, Andrew ;

Lubbe, Steven ;

Spain, Sarah ;

Sullivan, Kate ;

Fielding, Sarah ;

Jaeger, Emma ;

Vijayakrishnan, Jayaram ;

Kemp, Zoe ;

Gorman, Maggie ;

Chandler, Ian ;

Papaemmanuil, Elli ;

Penegar, Steven ;

Wood, Wendy ;

Sellick, Gabrielle ;

Qureshi, Mobshra ;

Teixeira, Ana ;

Domingo, Enric ;

Barclay, Ella ;

Martin, Lynn ;

Sieber, Oliver ;

Kerr, David ;

Gray, Richard ;

Peto, Julian ;

Cazier, Jean-Baptiste ;

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Houlston, Richard S. .

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Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

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Boorman, James P. ;

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Everson, Ursula ;

Hussey, Judith M. ;

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Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

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Garcia-Closas, Montserrat ;

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Pooley, Karen A. ;

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Baynes, Caroline ;

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Lissowska, Jolanta ;

Brinton, Louise ;

Peplonska, Beata ;

Southey, Melissa C. ;

Hopper, John L. ;

McCredie, Margaret R. E. ;

Giles, Graham G. ;

Fletcher, Olivia ;

Johnson, Nichola ;

dos Santos Silva, Isabel ;

Gibson, Lorna ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Torres, Diana ;

Hamann, Ute ;

Justenhoven, Christina ;

Brauch, Hiltrud ;

Chang-Claude, Jenny ;

Kropp, Silke ;

Risch, Angela ;

Wang-Gohrke, Shan ;

Schuermann, Peter ;

Bogdanova, Natalia ;

Doerk, Thilo ;

Fagerholm, Rainer ;

Aaltonen, Kirsimari ;

Blomqvist, Carl ;

Nevanlinna, Heli ;

Seal, Sheila ;

Renwick, Anthony ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Sangrajrang, Suleeporn ;

Hughes, David ;

Odefrey, Fabrice ;

Brennan, Paul ;

Spurdle, Amanda B. ;

Chenevix-Trench, Georgia ;

Beesley, Jonathan .

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Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

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Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

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Gudmundsson, Julius ;

Sulem, Patrick ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Manolescu, Andrei ;

Gudbjartsson, Daniel ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Blondal, Thorarinn ;

Jakobsdottir, Margret ;

Stacey, Simon N. ;

Kostic, Jelena ;

Kristinsson, Kari T. ;

Birgisdottir, Birgitta ;

Ghosh, Shyamali ;

Magnusdottir, Droplaug N. ;

Thorlacius, Steinunn ;

Thorleifsson, Gudmar ;

Zheng, S. Lilly ;

Sun, Jielin ;

Chang, Bao-Li ;

Elmore, J. Bradford ;

Breyer, Joan P. ;

McReynolds, Kate M. ;

Bradley, Kevin M. ;

Yaspan, Brian L. ;

Wiklund, Fredrik ;

Stattin, Par ;

Lindstrom, Sara ;

Adami, Hans-Olov ;

McDonnell, Shannon K. ;

Schaid, Daniel J. ;

Cunningham, Julie M. ;

Wang, Liang ;

Cerhan, James R. ;

St Sauver, Jennifer L. ;

Isaacs, Sara D. ;

Wiley, Kathleen E. ;

Partin, Alan W. ;

Walsh, Patrick C. ;

Polo, Sonia ;

Ruiz-Echarri, Manuel ;

Navarrete, Sebastian ;

Fuertes, Fernando ;

Saez, Berta ;

Godino, Javier ;

Weijerman, Philip C. ;

Swinkels, Dorine W. ;

Aben, Katja K. .

NATURE GENETICS, 2008, 40 (03) :281-283

[9] Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Manolescu, Andrei ;

Amundadottir, Laufey T. ;

Gudbjartsson, Daniel ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Xu, Jianfeng ;

Blondal, Thorarinn ;

Kostic, Jelena ;

Sun, Jielin ;

Ghosh, Shyamali ;

Stacey, Simon N. ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Kristjansson, Kristleifur ;

Tres, Alejandro ;

Partin, Alan W. ;

Albers-Akkers, Marjo T. ;

Marcos, Javier Godino-Ivan ;

Walsh, Patrick C. ;

Swinkels, Dorine W. ;

Navarrete, Sebastian ;

Isaacs, Sarah D. ;

Aben, Katja K. ;

Graif, Theresa ;

Cashy, John ;

Ruiz-Echarri, Manuel ;

Wiley, Kathleen E. ;

Suarez, Brian K. ;

Witjes, J. Alfred ;

Frigge, Mike ;

Ober, Carole ;

Jonsson, Eirikur ;

Einarsson, Gudmundur V. ;

Mayordomo, Jose I. ;

Kiemeney, Lambertus A. ;

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[10] A common genetic risk factor for colorectal and prostate cancer [J].

Haiman, Christopher A. ;

Le Marchand, Loic ;

Yamamato, Jennifer ;

Stram, Daniel O. ;

Sheng, Xin ;

Kolonel, Laurence N. ;

Wu, Anna H. ;

Reich, David ;

Henderson, Brian E. .

NATURE GENETICS, 2007, 39 (08) :954-956

← 1 2 3 →

共 28 条

[1] A haplotype map of the human genome [J].

Altshuler, D ;

Brooks, LD ;

Chakravarti, A ;

Collins, FS ;

Daly, MJ ;

Donnelly, P ;

Gibbs, RA ;

Belmont, JW ;

Boudreau, A ;

Leal, SM ;

Hardenbol, P ;

Pasternak, S ;

Wheeler, DA ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Zeng, CQ ;

Gao, Y ;

Hu, HR ;

Hu, WT ;

Li, CH ;

Lin, W ;

Liu, SQ ;

Pan, H ;

Tang, XL ;

Wang, J ;

Wang, W ;

Yu, J ;

Zhang, B ;

Zhang, QR ;

Zhao, HB ;

Zhao, H ;

Zhou, J ;

Gabriel, SB ;

Barry, R ;

Blumenstiel, B ;

Camargo, A ;

Defelice, M ;

Faggart, M ;

Goyette, M ;

Gupta, S ;

Moore, J ;

Nguyen, H ;

Onofrio, RC ;

Parkin, M ;

Roy, J ;

Stahl, E ;

Winchester, E ;

Ziaugra, L ;

Shen, Y .

NATURE, 2005, 437 (7063) :1299-1320

[2] A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk [J].

Broderick, Peter ;

Carvajal-Carmona, Luis ;

Pittman, Alan M. ;

Webb, Emily ;

Howarth, Kimberley ;

Rowan, Andrew ;

Lubbe, Steven ;

Spain, Sarah ;

Sullivan, Kate ;

Fielding, Sarah ;

Jaeger, Emma ;

Vijayakrishnan, Jayaram ;

Kemp, Zoe ;

Gorman, Maggie ;

Chandler, Ian ;

Papaemmanuil, Elli ;

Penegar, Steven ;

Wood, Wendy ;

Sellick, Gabrielle ;

Qureshi, Mobshra ;

Teixeira, Ana ;

Domingo, Enric ;

Barclay, Ella ;

Martin, Lynn ;

Sieber, Oliver ;

Kerr, David ;

Gray, Richard ;

Peto, Julian ;

Cazier, Jean-Baptiste ;

Tomlinson, Ian ;

Houlston, Richard S. .

NATURE GENETICS, 2007, 39 (11) :1315-1317

[3] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[4] Genomics - When the smoke clears ... [J].

Chanock, Stephen J. ;

Hunter, David J. .

NATURE, 2008, 452 (7187) :537-538

[5] A common coding variant in CASP8 is associated with breast cancer risk [J].

Cox, Angela ;

Dunning, Alison M. ;

Garcia-Closas, Montserrat ;

Balasubramanian, Sabapathy ;

Reed, Malcolm W. R. ;

Pooley, Karen A. ;

Scollen, Serena ;

Baynes, Caroline ;

Ponder, Bruce A. J. ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Brinton, Louise ;

Peplonska, Beata ;

Southey, Melissa C. ;

Hopper, John L. ;

McCredie, Margaret R. E. ;

Giles, Graham G. ;

Fletcher, Olivia ;

Johnson, Nichola ;

dos Santos Silva, Isabel ;

Gibson, Lorna ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Torres, Diana ;

Hamann, Ute ;

Justenhoven, Christina ;

Brauch, Hiltrud ;

Chang-Claude, Jenny ;

Kropp, Silke ;

Risch, Angela ;

Wang-Gohrke, Shan ;

Schuermann, Peter ;

Bogdanova, Natalia ;

Doerk, Thilo ;

Fagerholm, Rainer ;

Aaltonen, Kirsimari ;

Blomqvist, Carl ;

Nevanlinna, Heli ;

Seal, Sheila ;

Renwick, Anthony ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Sangrajrang, Suleeporn ;

Hughes, David ;

Odefrey, Fabrice ;

Brennan, Paul ;

Spurdle, Amanda B. ;

Chenevix-Trench, Georgia ;

Beesley, Jonathan .

NATURE GENETICS, 2007, 39 (03) :352-358

[6] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

[7] Multiple newly identified loci associated with prostate cancer susceptibility [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

[8] Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Manolescu, Andrei ;

Gudbjartsson, Daniel ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Blondal, Thorarinn ;

Jakobsdottir, Margret ;

Stacey, Simon N. ;

Kostic, Jelena ;

Kristinsson, Kari T. ;

Birgisdottir, Birgitta ;

Ghosh, Shyamali ;

Magnusdottir, Droplaug N. ;

Thorlacius, Steinunn ;

Thorleifsson, Gudmar ;

Zheng, S. Lilly ;

Sun, Jielin ;

Chang, Bao-Li ;

Elmore, J. Bradford ;

Breyer, Joan P. ;

McReynolds, Kate M. ;

Bradley, Kevin M. ;

Yaspan, Brian L. ;

Wiklund, Fredrik ;

Stattin, Par ;

Lindstrom, Sara ;

Adami, Hans-Olov ;

McDonnell, Shannon K. ;

Schaid, Daniel J. ;

Cunningham, Julie M. ;

Wang, Liang ;

Cerhan, James R. ;

St Sauver, Jennifer L. ;

Isaacs, Sara D. ;

Wiley, Kathleen E. ;

Partin, Alan W. ;

Walsh, Patrick C. ;

Polo, Sonia ;

Ruiz-Echarri, Manuel ;

Navarrete, Sebastian ;

Fuertes, Fernando ;

Saez, Berta ;

Godino, Javier ;

Weijerman, Philip C. ;

Swinkels, Dorine W. ;

Aben, Katja K. .

NATURE GENETICS, 2008, 40 (03) :281-283

[9] Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Manolescu, Andrei ;

Amundadottir, Laufey T. ;

Gudbjartsson, Daniel ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Xu, Jianfeng ;

Blondal, Thorarinn ;

Kostic, Jelena ;

Sun, Jielin ;

Ghosh, Shyamali ;

Stacey, Simon N. ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Kristjansson, Kristleifur ;

Tres, Alejandro ;

Partin, Alan W. ;

Albers-Akkers, Marjo T. ;

Marcos, Javier Godino-Ivan ;

Walsh, Patrick C. ;

Swinkels, Dorine W. ;

Navarrete, Sebastian ;

Isaacs, Sarah D. ;

Aben, Katja K. ;

Graif, Theresa ;

Cashy, John ;

Ruiz-Echarri, Manuel ;

Wiley, Kathleen E. ;

Suarez, Brian K. ;

Witjes, J. Alfred ;

Frigge, Mike ;

Ober, Carole ;

Jonsson, Eirikur ;

Einarsson, Gudmundur V. ;

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