Enteric absorption of FK 506: Estimation by a block liver perfusion technique in rats

被引：10

作者：

Watanabe, Y ^{[1
]}

Sato, M ^{[1
]}

Abe, Y ^{[1
]}

Yamamoto, T ^{[1
]}

Kashu, Y ^{[1
]}

Horiuchi, A ^{[1
]}

Hamada, Y ^{[1
]}

Nakata, T ^{[1
]}

Lee, T ^{[1
]}

Kawachi, K ^{[1
]}

机构：

[1] Ehime Univ, Dept Surg 2, Shigenobu, Ehime 79102, Japan

来源：

TRANSPLANTATION PROCEEDINGS | 1998年 / 30卷 / 07期

关键词：

D O I：

10.1016/S0041-1345(98)01233-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This perfusion model enables a pharmacokinetic study of enteral absorption and hepatic metabolic rate simultaneously. FK 506 is absorbed mainly via the proximal small intestine and metabolized rapidly by the liver during single passage. These results may lead to further analyses of absorption and metabolism of FK 506 under various conditions. © 1998 by Elsevier Science Inc.

引用

页码：3777 / 3778

页数：2

共 3 条

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