The evolving field of imaging mass spectrometry and its impact on future biological research

被引：107

作者：

Watrous, Jeramie D. ^{[2
]}

Alexandrov, Theodore ^{[1
]}

Dorrestein, Pieter C. ^{[2
,3
,4
]}

机构：

[1] Univ Bremen, Ctr Ind Math, Bremen, Germany

[2] Univ Calif San Diego, Dept Pharmacol, Dept Chem & Biochem, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol, La Jolla, CA 92093 USA

来源：

JOURNAL OF MASS SPECTROMETRY | 2011年 / 46卷 / 02期

关键词：

imaging mass spectrometry; MALDI; SIMS; DESI; informatics; data mining; spectral processing; IMS public database; LASER-DESORPTION/IONIZATION MALDI; ELECTROSPRAY-IONIZATION DESI; DIRECT TISSUE-ANALYSIS; ATMOSPHERIC-PRESSURE; METABOLIC EXCHANGE; TOF-SIMS; QUANTITATIVE-ANALYSIS; MOLECULAR ANALYSIS; PEAK ALIGNMENT; ION;

D O I：

10.1002/jms.1876

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Within the past decade, imaging mass spectrometry (IMS) has been increasingly recognized as an indispensable technique for studying biological systems. Its rapid evolution has resulted in an impressive array of instrument variations and sample applications, yet the tools and data are largely confined to specialists. It is therefore important that at this junction the IMS community begin to establish IMS as a permanent fixture in life science research thereby making the technology and/or the data approachable by non-mass spectrometrists, leading to further integration into biological and clinical research. In this perspective article, we provide insight into the evolution and current state of IMS and propose some of the directions that IMS could develop in order to stay on course to become one of the most promising new tools in life science research. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：209 / 222

页数：14

共 138 条

[11] Quantitative mass spectrometry in proteomics: a critical review [J].

Bantscheff, Marcus ;

Schirle, Markus ;

Sweetman, Gavain ;

Rick, Jens ;

Kuster, Bernhard .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2007, 389 (04) :1017-1031

[12] Quantitative imaging of selenium, copper, and zinc in thin sections of biological tissues (Slugs-Genus arion) measured by laser ablation inductively coupled of plasma mass spectrometry [J].

Becker, J. S. ;

Matusch, A. ;

Depboylu, C. ;

Dobrowolska, J. ;

Zoriy, M. V. .

ANALYTICAL CHEMISTRY, 2007, 79 (16) :6074-6080

[13] Bioimaging of metals in brain tissue from micrometre to nanometre scale by laser ablation inductively coupled plasma mass spectrometry: State of the art and perspectives [J].

Becker, J. Sabine .

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2010, 289 (2-3) :65-75

[14]

BECKER M, 2010, J BIOMOL TECHNOL, V21, pS33

[15]

Bell AW, 2009, NAT METHODS, V6, P423, DOI [10.1038/NMETH.1333, 10.1038/nmeth.1333]

[16] IMPACT OF SLOW GOLD CLUSTERS ON VARIOUS SOLIDS - NONLINEAR EFFECTS IN SECONDARY ION EMISSION [J].

BENGUERBA, M ;

BRUNELLE, A ;

DELLANEGRA, S ;

DEPAUW, J ;

JORET, H ;

LEBEYEC, Y ;

BLAIN, MG ;

SCHWEIKERT, EA ;

BENASSAYAG, G ;

SUDRAUD, P .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1991, 62 (01) :8-22

[17] SURFACE MS - PROBING REAL-WORLD SAMPLES [J].

BENNINGHOVEN, A ;

HAGENHOFF, B ;

NIEHUIS, E .

ANALYTICAL CHEMISTRY, 1993, 65 (14) :A630-A640

[18] Dealing with the Unknown: Metabolomics and Metabolite Atlases [J].

Bowen, Benjamin P. ;

Northen, Trent R. .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2010, 21 (09) :1471-1476

[19] Advances in Imaging Secondary Ion Mass Spectrometry for Biological Samples [J].

Boxer, Steven G. ;

Kraft, Mary L. ;

Weber, Peter K. .

ANNUAL REVIEW OF BIOPHYSICS, 2009, 38 :53-74

[20] Combined chemical and topographic imaging at atmospheric pressure via microprobe laser desorption/ionization mass spectrometry-atomic force microscopy [J].

Bradshaw, James A. ;

Ovchinnikova, Olga S. ;

Meyer, Kent A. ;

Goeringer, Douglas E. .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2009, 23 (23) :3781-3786

← 1 2 3 4 5 6 7 8 9 10 →