Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

被引：731

作者：

Dechat, Thomas ^{[1
]}

Pfleghaar, Katrin ^{[1
]}

Sengupta, Kaushik ^{[1
]}

Shimi, Takeshi ^{[1
]}

Shumaker, Dale K. ^{[1
]}

Solimando, Liliana ^{[1
]}

Goldman, Robert D. ^{[1
]}

机构：

[1] Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 07期

关键词：

lamins; chromatin; epigenetics; nuclear architecture; laminopathies; viruses;

D O I：

10.1101/gad.1652708

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Over the past few years it has become evident that the intermediate filament proteins, the types A and B nuclear lamins, not only provide a structural framework for the nucleus, but are also essential for many aspects of normal nuclear function. Insights into lamin-related functions have been derived from studies of the remarkably large number of disease-causing mutations in the human lamin A gene. This review provides an up-to-date overview of the functions of nuclear lamins, emphasizing their roles in epigenetics, chromatin organization, DNA replication, transcription, and DNA repair. In addition, we discuss recent evidence supporting the importance of lamins in viral infections.

引用

页码：832 / 853

页数：22

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